Ozgene, a leading provider of genetically modified mice for medical research, has developed goGermline, a new technology to generate knockout and knock-in mice.
Online PR News – 20-August-2014 – Perth/Western Australia – Ozgene, a leading provider of genetically modified mice for medical research, has developed a new technology called goGermline. This technology produces genetically modified mice faster, more efficiently and with significantly fewer animals. As such, goGermline has a major positive impact on animal welfare within knockout and knock-in mouse model production. This new technology is part of Ozgene’s overall mission “to advance humanity - inspire curiosity”.
Traditionally, genetic modification is done in mouse embryonic stem cells (ESC) from which a chimeric mouse is created. When mated, a percentage of the chimeric offspring are from the modified ESC that carry the genetic modification. However, this also inevitably produces mice that are not ESC derived and therefore unnecessary.
goGermline technology addresses this issue by generating only the ESC offspring, with significantly less unnecessary mice being produced. goGermline has a number of benefits. From an animal welfare point of view it improves the three R’s (Replace, Reduce, Refine). From a researchers point of view it improves production timelines and efficiencies in making knockout and knock-in mouse models.
For more information regarding goGermline technology, please contact Ozgene by visiting www.ozgene.com/goGermline
About the company: Ozgene is a global provider of custom designed knockout, knock-in and transgenic mice, with a demonstrated track record of successful mouse model generation, specialising in C57BL/6 strain. Ozgene has over two decades of experience in the field, and more than 250 research papers have been published using Ozgene mice.